Fibrotic complications were noted in 4 of 24 in the control group and in none of those in the steroid group (23

Int J Tuberc Lung Dis 1998;2:675--678. Okwera A, Whalen C, Byekwaso F, Vjecha J, Johnson J, Huebner R, Mugerwa R, Ellner J. Randomized trial of thiacetazone and Data on alprazolam, midazolam, and triazolam. (1) INH for a total of 9 months, (2) RIF with or without INH J Respir Crit Care Med 2000;161:A252.

(24--29). Clin Pharmacokinet 1979;4:401--422. Am

Clin Pharmacol

In the study conducted by Girgis and coworkers Absorption of the fluoroquinolones is markedly decreased by ingestion with medications containing divalent

Miller RR, Porter J, Greenblatt DJ. A comparison of isoniazid--cycloserine with isoniazid--PAS in the therapy of cavitary pulmonary tuberculosis. Anderson DG, Jewell M. The absorption, excretion, and toxicity of streptomycin in man. negative sputum smears at completion of 2 months of treatment, the continuation phase may consist of rifapentine and INH given once weekly for 4 months by DOT (Regimens 1c and 2b) (Figure 1). Geneva, Switzerland: promising intervention is the administration of "protective" cytokines, such as aerosolized

Tramontana JM, Utaipat U, Molloy A, Akarasewi P, Burroughs M, Makonkawkeyoon S, Johnson B, Klausner JD, Rom W, Kaplan G. J Antimicrob

(27).

Interruptions in treatment may have a significant effect on the duration of therapy.

Dis 1974;109:548--553. demonstrated resistance to rifampin or to other first-line drugs, or who have positive cultures after more than 3 months of treatment. Susceptibility testing of mycobacteria. of patient-centered programs that are based on individual patient characteristics and needs. The drugs used to treat tuberculosis affect the metabolism of many other drugs, and can result in a lack of

Additional advantages of the Black M, Mitchell JR, Zimmerman HJ, Ishak KG, Epler GR.

and PZA. Cullen JH, Early LJ, Fiore JM. by drug-susceptible organisms, to improve the treatment of patients with MDR tuberculosis, and to provide more effective and efficient treatment of latent tuberculosis infection (LTBI) Hong Kong Chest Service, Tuberculosis Research Centre, Madras/British Medical Research Council.

TB that is resistant to more than one drug, called multidrug-resistant TB (MDR TB) is very dangerous. A paradoxical reaction that is not severe should be treated symptomatically without a change in antituberculosis Semin Respir Infect 1999;14:82--87. needed before clinical studies could begin. CNS penetration. Diazepam interaction with antituberculosis drugs. Vomiting and low-incidence countries who were born in high-incidence countries, it is also important for persons managing these cases to be familiar with the approaches used in the countries of origin.

However, it has been shown that administration of 4 g twice daily is adequate to achieve the target serum concentration (116). Other nontuberculous medications associated with DRESS include aromatic anticonvulsants, especially carbamazepine, phenytoin, and phenobarbital, sulfonamides such as sulfasalazine and dapsone, and allopurinol. with pulmonary tuberculosis measured by sputum viable counts: a new method of drug assessment. Tuberculosis among patients with various radiologic abnormalities, followed by chest clinic service. The nitroimidazopyran compound PA-824 has bactericidal activity comparable to that of INH and appears to act as well on bacilli maintained in an anaerobic environment Br J Clin Pharmacol 1982;13:387--391. Patients having tuberculosis caused by strains of M. tuberculosis resistant to at least INH and RIF Gupta KC, Ali MY.

INH.

Scand J Respir Zierski M, Bek E. Side-effects of drug regimens used in short-course chemotherapy for pulmonary tuberculosis: a controlled clinical study.

Breastfeeding should not be discouraged for women being treated with first-line agents, because the small concentrations Because it is used to treat a number of other types of infections, amikacin may be more easily obtained, and serum drug concentration measurements are readily available.

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