Serologic testing is not recommended before or after receiving tetanus toxoid-containing vaccine.

It is prudent to not administer further doses of tetanus toxoid-containing vaccine to persons who develop GBS within 6 weeks of receiving such vaccine. Tetanus is characterized by muscle spasms, usually in a descending pattern, beginning in the jaw muscles. In 1994, 10 cases were reported. Refer to Diphtheria Toxoid, Pertussis Vaccine, Poliomyelitis Vaccine, Haemophilus influenzae type b Vaccine and Hepatitis B Vaccine in Part 4 for additional information. Infants and children receive tetanus toxoid in combination with diphtheria toxoid and acellular pertussis, as DTPa (diphtheria-tetanus-acellular pertussis)-containing vaccines.. After the initial tetanus series, booster shots are recommended every 10 years. It has no effect on toxin already fixed to nerve tissue. There were zero deaths by the year 1975, and between 1982 and 1987, 1991 and 1993, and none whatsoever since 1998 until the end of the reporting period. TIg provides immediate passive protection until the exposed person mounts an immune response to the tetanus toxoid. Refer to Vaccine Safety in Part 2 for additional general information. When considering immunization of an immunocompromised person, consultation with the individual's attending physician may be of assistance, in addition to the guidance provided in Immunocompromised persons in Diphtheria Toxoid and Haemophilus influenzae type b Vaccine in Part 4. For complex cases, referral to a physician with expertise in immunization or immunodeficiency is advised. Some individuals with humoral immune deficiency (e.g., HIV, agammaglobulinemia or hypogammaglobulinemia) may not respond adequately to tetanus toxoid-containing vaccine. The preschool booster dose of either DTaP-IPV or Tdap-IPV vaccine should be administered at 4 to 6 years of age. An adult who's never been immunized against tetanus should complete the initial tetanus series of three tetanus shots. Tetanus toxoid-containing vaccine is recommended for routine infant immunization, beginning at 2 months of age. Adults who have not previously received a primary series (at least 3 doses) of tetanus toxoid-containing vaccine should receive one dose of Tdap-IPV vaccine and two doses of Td-IPV vaccine. A booster dose of either DTaP-IPV or Tdap-IPV vaccine should be administered at 4 to 6 years of age (school entry). It is important to ascertain the number of doses of tetanus toxoid-containing vaccine that an injured person previously has received, any severe reaction that they have experienced with any previous dose, and the interval since the last dose. Adolescents should routinely receive a booster dose of Tdap vaccine at 14 to 16 years of age. The deaths declined to 33 by 1926 only to hit another peak by 1927 declining sharply to 33 by 1929. Routine tetanus immunization of infants: DTaP-IPV-Hib vaccine should be given at 2, 4, 6 and 12 to 23 months of age (generally given at 18 months of age). A primary series and boosters, including post-exposure boosters, are recommended to develop and maintain high circulating concentrations of tetanus antibody in the event of exposure to. The immunization status of the reported cases was not known. Tetanus (lockjaw) is caused by a neurotoxin produced by the bacterium Clostridium tetani. C. tetani spores are widely distributed in soil worldwide and have also been detected in the intestines of animals and humans. Figure 1: Tetanus - number of cases and deaths, Canada, 1921-2010, Efficacy, Effectiveness and Immunogenicity, Table 1: Guide to tetanus prophylaxis in wound management, Simultaneous Administration with Other Vaccines, Vaccine and Immunoglobulin Safety and Adverse Events, Contents of Immunizing Agents Available for Use in Canada, Immunization of Persons with Inadequate Immunization Records, Immunization in Pregnancy and Breastfeeding, Immunization of Persons in Health Care Institutions, Immunization of Immunocompromised Persons, Immunization of Persons with Chronic Diseases, Storage and Handling of Immunizing Agents, Reporting Adverse Events Following Immunization, Contents of Immunizing Agents Available for use in Canada, Contraindications Precautions and concerns, Unknown or less than 3 doses in a vaccine series. Refer to Vaccine Safety for safety information.

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