pp 27-32 | Most of the time, they stay inactive until they get prompted to divide by physical or chemical factors. In the samples of live cells, CD44 was the only marker that was detected at levels that were similar to those in fixed cell samples. The chapter discuses definition of stem cells and their classification based on differentiation potential and origin.

For example, Trop2, ... Several stem cell markers including CXCR4 and CD117 were associated with increased angiogenesis and escape from tumor hypoxia [37, 88]. Elsevier Inc. Chap.

60, 61 Although it is expressed predominantly in stem cells of the central nervous system (CNS) , 62 its expression is absent from nearly all mature CNS cells. Markers are protein products of clonal expansion, during self-renewal of stem cells, where the entire energy is invested in their multiplication.

There is increasing evidence that subpopulations of neoplastic cells demonstrate heterogeneity with respect to proliferation, differentiation, and expression of cellular proteins characteristic of  stem cells. Proc Natl Acad Sci U S A 104:16438–16443, Andrews P, Banting G, Damjanov I, Arnaud D, Avner P (1984) Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. Neural Stem Cell Markers. Microscopically, cancer stem cells outwardly appear the same as any other tumor cell. Characteristics There is increasing evidence that subpopulations of neoplastic cells demonstrate heterogeneity with respect to proliferation, differentiation, and expression of cellular proteins characteristic of stem cells . These data indicate that additional combination therapies with antiangiogenic or antihypoxia inducible factor-1 α treatments may have improved efficacy over a single therapy. Leuk Lymphoma 47(10):2017–2027, https://doi.org/10.1007/978-3-642-16483-5, Reference Module Biomedical and Life Sciences. Curr Biol 11:514–518, Herzenberg LA, De Rosa SC (2000) Monoclonal antibodies and the FACS: complementary tools for immunobiology and medicine. Self-renewal and lack of differentiation are also features of stem cells and have been associated with the expression of embryonic genes. Cite as. Cell 115:281–292, Mountford J (2008) Human embryonic stem cells: origins, characteristics and potential for regenerative therapy. Urine stem cells (USC) express a variety of markers for pericyte, MSC, and pluripotent stem cell markers ... An explanation is also unknown for the differences in the gene expression of the urine cell markers in different samples obtained from the same individual at different times (intra-variability). However, the proportions of CD24 + /CD44 + /EpCAM + and CD24 + /CD44 + /CD133 + cells were markedly lower and ranged from 0.4 to 1.14% and from 0 to 1.43%, respectively.

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