compared two fludarabine-based conditioning regimens (FluMel versus FluCy) in relapsed/refractory HL patients. For some relapsed/refractory patients a form of immunotherapy called chimeric antigen receptor (CAR) T-cell therapy, may be a possible treatment option. A stem cell transplant is sometimes used to treat non-Hodgkin lymphoma (NHL).

Information regarding the role of allogeneic SCT for HL in the pediatric population is very limited.

Therefore, it remains difficult to draw final conclusions concerning the most appropriate intensity of conditioning for relapsed/refractory HL patients who failed to achieve cure by high dose chemotherapy and autologous SCT.

Fourteen patients (67%) had a history of previous HD-SCT.

Results of the HDR-ALLO study - a prospective clinical trial by the Grupo Español de Linfomas/Trasplante de Médula Osea (GEL/TAMO) and the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. Case 1 documents a strategy of dose manipulation according to PET response and GVHD, allowing the formation of a sustained equilibrium between disease control and GVHD.

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Phase II results with the monoclonal antibody SGN-30,”.

A. O'Connor, M. L. Heaney, L. Schwartz et al., “Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies,”, B. Böll, P. Borchmann, M. S. Topp et al., “Lenalidomide in patients with refractory or multiple relapsed Hodgkin lymphoma,”, T. A. Fehninger, S. Larson, K. Trinkaus et al., “A phase II multicenter study of lenalidomide in patients with relapsed or refractory classical Hodgkin Lymphoma (cHL): preliminary results,”, Y. Oki, B.

).


ASCO Meetings
Despite no further pembrolizumab, PET continued to demonstrate CR 6 months after the initial dose. Stiff, A. For instance, in chronic myeloid leukemia (CML), or multiple myeloma, allogeneic SCT as well as donor lymphocytes infusions (DLIs) being applied due to posttransplant disease recurrence were significantly associated with response [35–37]. Contact Us In addition, a pivotal trial with brentuximab—a novel agent consisting of an anti-CD30 monoclonal antibody and monomethyl auristatin E, an antimitotic agent—was recently completed [83]. For haploidentical SCT, the authors used a fludarabine/cyclophosphamide regimen combined with TBI (2 Gy).

The 5-year rate of progression was significantly higher in the RIC when compared to the MAC cohort (58% versus 32%, resp. ASCO Connection

Meeting Abstracts, About However, management of disease refractory to primary induction or relapsing after remission becomes challe There is no doubt that the use of RIC improves OS in selected patients, but is linked to high relapse rates.

High-dose myeloablative therapy with autologous or allogeneicstem cell rescue is an effective treatment strategy for non-Hodgkin’slymphoma (NHL), but NHL is much less likely to stay in remission afteran autologous transplant than after an allogeneic transplant. MAC regimens were based on combinations of cyclophosphamide with high-dose TBI (

We use cookies to help provide and enhance our service and tailor content and ads. JCO Precision Oncology, ASCO Educational Book compared safety and efficacy of RIC-SCT using either unrelated umbilical cord blood (UCB, 3744-3753. Pro, L. E. Fayad et al., “Phase 2 study of gemcitabine in combination with rituximab in patients with recurrent or refractory Hodgkin lymphoma,”, K. S. Reiners, A. Gossmann, E. P. Von Strandmann, B. Böll, A. Engert, and P. Borchmann, “Effects of the anti-VEGF Monoclonal antibody bevacizumab in a preclinical model and in patients with refractory and multiple relapsed hodgkin lymphoma,”.

The results of the study were disappointing: owing to high relapse (65%) and nonrelapse mortality rates (61%), 3-year overall (OS) and disease free survival (DFS) rates were only 21% and 15%, respectively.

At the time of the report, nine patients were alive, of those seven in continuous complete remission (1 to 21 months from allogeneic SCT), while only one patient had died due to progression [22].

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