Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons. Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches. We recommend that commenters identify themselves with full names and affiliations. A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex. 2019, Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder, Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium, We use cookies to help provide and enhance our service and tailor content and ads. Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons. Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats. Copyright © 2020 Elsevier Inc. except certain content provided by third parties. Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels. hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease. Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat. The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum. Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. May 11,

A simple and efficient system for regulating gene expression in human pluripotent stem cells and derivatives. Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years. Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats. Dual RMCE for efficient re-engineering of mouse mutant alleles. Equalizing excitation-inhibition ratios across visual cortical neurons. Robust pacemaking in substantia nigra dopaminergic neurons. Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior. Institute of Pediatrics, Children’s Hospital, Fudan University, 399 Wanyuan Road, Shanghai 201102, China, Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA, Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China, Human ESC-derived mDA neurons exhibit A9-like DA neuron characteristics, Functional synaptic inputs depend on the grafted neuronal type but not graft site, Human mDA neurons repair the nigra-striatal circuit with precision, Functionally repaired nigra-striatal circuit restores animal behavior, Although cell transplantation can rescue motor defects in Parkinson’s disease (PD)

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