For general information, Learn About Clinical Studies. Participation for granulocyte donors will last 1 week from the time of donation. Community donors may provide more than one granulocyte donation, but no more than one donation every 3 days.

Transfusions will be stopped if participants start making their own granulocytes, experience serious side effects, or show a reduction in infection.

To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. The severely reduced immunity of those with neutropenia can put them at risk of entry of life-threatening infections, making the implementation of treatments that increase white blood cell numbers important. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Do you have a limit on the number of times per year a donor may donate granulocytes. At Month 3 after study entry, follow-up information will be collected about all participants' health status through reviewing their medical records and contacting their physicians.
Get the latest research information from NIH: You have reached the maximum number of saved studies (100). Talk with your doctor and family members or friends about deciding to join a study. An apheresis granulocyte donor returning to whole blood donation should wait a minimum of eight weeks. The extra effort on the part of these donors is extraordinary. Your email address will not be published.

Your email address will not be published.
Normally, no more than three donations should be collected from a female donor and four from a male donor during any 12-month period. I’m a platelet donor: That takes about two hours.  (Clinical Trial), High Dose Granulocyte Transfusions for the Treatment of Infection in Neutropenia: The RING Study (Resolving Infection in Neutropenia With Granulocytes), Baltimore, Maryland, United States, 21267, Boston, Massachusetts, United States, 02115, Minneapolis, Minnesota, United States, 55455, Weill Medical College, Cornell University, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States, 73104, Philadelphia, Pennsylvania, United States, 19104, University of Pittsburgh Presbyterian and Shadyside, Pittsburgh, Pennsylvania, United States, 15213, Seattle, Washington, United States, 98195, Milwaukee, Wisconsin, United States, 53201, Children's Hospital Boston/Brigham and Women's Hospital, University of Pittsburgh Presbyterian and Shadyside/Children's Hospital Pittsburgh, Percentage of Participants Who Are Alive at 42 Days After Treatment and Have Had Microbial Response [ Time Frame: Measured at Day 42 ]. Community donors may provide more than one granulocyte donation, but no more than one donation every 3 days. Granulocytes are only collected upon a physician’s request for a specific patient need. In order to post comments, please make sure JavaScript and Cookies are enabled, and reload the page. COVID-19 is an emerging, rapidly evolving situation. Granulocytes are truly a life-saving blood product.

That’s quite a commitment to donate granulocytes – three hours! Daily blood samples to measure white blood cell count will be obtained from participants until samples show that participants are making their own granulocytes.

A negative blood culture test at 42 days after randomization for subjects with fungemia (candidemia or fusariosis) or bacteremia.

The extra effort on the part of these donors is extraordinary. 3.6.2: Plasma and plateletpheresis Microbial response was defined as follows: Choosing to participate in a study is an important personal decision.

Alloimmunization, Defined as the Appearance of Anti-human Leukocyte Antigen (HLA) or Antineutrophil Antibodies [ Time Frame: Measured at Days 14 and 42 ], Serious Granulocyte Transfusion Reactions, Including Febrile, Allergic, and Pulmonary Reactions (Transfusion Arm Only) [ Time Frame: Measured within 6 hours after end of transfusion ], Graft Versus Host Disease Among Recipients of Allogeneic Stem Cell Transplantation [ Time Frame: Measured at Day 42 ], Overall Incidence of Adverse Effects [ Time Frame: Measured through Day 42 ], Fever Resolution [ Time Frame: Measured through Day 42 ], Time to Negative Test for Fungal Antigenemia (e.g., Galactomannan Antigenemia Among Participants With Invasive Aspergillosis) [ Time Frame: Measured at Days 7, 14, and 42 ], Time to Negative Blood Culture for Participants With Positive Blood Culture at Baseline [ Time Frame: Measured through Day 42 ], Long-term Survival [ Time Frame: Measured at Month 3 ], Serious Adverse Events in Granulocyte Donors [ Time Frame: Measured at Week 1 after G-CSF administration ], Donor Availability (Proportion of Scheduled Granulocyte Transfusion Days on Which Granulocytes Were Available) [ Time Frame: Measured through study completion ], Evaluation of Granulocyte Yield [ Time Frame: Measured immediately after each granulocyte donation ], Discontinuation of Granulocyte Transfusions Due to Toxicity or Intolerance [ Time Frame: Measured through Day 42 ], Severe neutropenia (Absolute Neutrophil Count < 500/mm^3) due to marrow failure caused by underlying disease or therapy, Must have one of the following: fungemia; bacteremia; proven or presumptive invasive tissue bacterial infection; or proven, probable, or presumptive invasive fungal infection, Evidence that patient will not be neutropenic at least 5 days. The procedure will last 3 to 4 hours and will involve the drawing of blood from each arm, the separation of granulocytes from the red cells and plasma in the machine, and the return of the red cells and plasma to the participants. Participants will undergo the recommended therapy for specific infections for 42 days.

Participants will then be assigned randomly to receive either granulocyte transfusion plus continued antimicrobial therapy or continued antimicrobial therapy alone. There may be additional blood draws depending on the type of infection present in participants.

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