endobj 2013-07-10T10:27:23-04:00 The toxin unit (the smallest amount of toxin required to kill a guinea-pig weighing 300 gm. endobj Are we ready for diphtheria?

London: The Pharmacopeial Press; 1996. p. 1617.

The concentration of diphtheria antitoxin is 10 IU/ml. Follow the instructions regarding investigational product accountability and disposition upon completion of patient’s pharmaceuticals Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. <>/OutputIntents[<>] /Metadata 343 0 R/ViewerPreferences 344 0 R>> &'()*6789:EFGHIJUVWXYZefghijuvwxyz����������������������������������������������������������� XG This section is from the book "A Manual Of Pathology", by Guthrie McConnell. *�.�9�3�R�:#��#�U6Ci;���VXB�G����`&rPd���OM��p�D�r,is�����0��r�K���oy�%�ɜ�&��I�*�������Ĭ ���� �L`��H0��)�� #�:���`�i���� ր�'.��JX��4;���৘��YY���2|�.�ReefP`�����;����\,X�y�!������"��8��e`������0��%�9�b`(�˲N RE,��C (A|� endobj Wong TP, Groman N. Production of diphtheria toxin by selected isolates of Corynebacterium ulserans and Corynebacterium pseudotuberculosis. 2013-07-09T12:48:24Z

By E. KLEIN, M.D., F.R.S. Ehrlich, in determining the unit, makes use of a standard antitoxin (antitoxins not deteriorating or varying as do toxins) by which the antitoxin combining power of the test toxic bouillon is first determined. 1 0 obj %PDF-1.5 %���� Clostridium botulinum, pharmaceuticals, animal testing, mouse ��a���.����|�Cp�т ��r��R��St�Z�H�n�vEJu�`; ���1$�L����!��F�՜I����"~Ô[�eV�����m[����s������D:e�F@�*���o6����4*��p�?0�f0�rn_=�����]m]��K�e���6�0N�I��!K�� 6. h�b```��,�7@ (� When these disappear, a second dose is given.
When the degree of immunity is sufficiently high, blood is drawn from the jugular vein to the amount of from 3 to 9 liters, according to the size of the horse, collected in sterile bottles, then placed on ice for several days until the clear serum separates from the clot. %%EOF endobj

BMJ 1995; 311: 731-3.

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European Pharmacopeia 5.0 Fisher M. Treatment of acute anaphylaxis. In: Peter G, editor. As similar methods are used for practically all types of toxins, a description of the preparation of diphtheria antitoxin will be sufficient. application/pdf CPS Compendium of pharmaceuticals and specialties. 4 0 obj *++9+*./45554/;;;;;;;;;;;;;;;;;;;;; $2(!

An antitoxic unit may be defined as being ten times the least quantity of antitoxic serum that will protect a standard (300-gm.) 1 0 obj Diphtheria toxoid is not given as a single injection, but rather is combined with tetanus toxoid and, often, pertussis vaccine in a preparation called Tdap, DTaP, Td, or DT.

31st ed. Topical Scratch test for diphtheria hypersensititvity 1 drop of 1:100 diluion of equine diphtheria antitoxin is placed on the skin and a 0.64 cm scratch is made through the drop. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. DIRECTIONS FOR OPENING Vials have a „flip-up‟ circular cap.
mouse This is frequently followed by a rise in temperature, local reaction, and some general disturbance.

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