Single administration (single dose) of the methanol extract (200 and 400 mg/kg, p.o.) Tuberculosis is a bacterial infection caused by Mycobacterium tuberculosis (MTB). against drug sensitive and drug resistant Mycobacterium tuberculosis and MOTT clinical isolates. The Medicinal Chemistry Course • ADME (adsorption, distribution, metabolism and excretion) of drugs • drug-receptor interactions • development of drugs • screening techniques • combinatorial chemistry (D.O.) The medicinal plants in the control of tuberculosis: Laboratory study on medicinal plants from the Northern Area of Pakistan.


They are formed by interaction of sulfydryl group of aglycone & hydroxyl group of glycone.
Highest activities were observed in chloroform extract of C. colocynthis (leaves) and n-hexane extract of R. communis (seeds) with minimum inhibitory concentration values of 2.5 mg/ml each. The antinociceptive response using writhing and tail immersion test in mice were examined.

 |  Get the latest research from NIH: https://www.nih.gov/coronavirus. Screening for diuretic and laxative activity was performed on petroleum ether, chloroform and methanol extracts of the barks of S. pinnata. The methanol extract of S. pinnata barks significantly reduced the numbers of writhings induced by intraperitoneal injection of acetic acid in mice at all tested dose levels in a dose dependant manner, where as the mean latency of nociceptive responses to thermal stimuli in the tail immersion test of the methanol extract of S. pinnata barks also exhibited significant response at all tested dose levels in a dose dependant manner that is comparable with response of the standard drug pentazocine (30mg/kg, p.o.). suppressed the fever induced by yeast in rats from 1st hour of drug administration.

TB, historical perspective of anti TB drugs and medicinal chemistry of INH. The result of the methanol extract is comparable to that of the reference standard glibenclamide (2.5 mg/kg, p.o.). Aspirin (200 mg/kg, p.o.)

Since there is no inbuilt scientific proof in support of the utility of these plants or plant products against such diseases, the author felt it emergent and urgent to selects these plants for the present study in this dissertation. It gave positive Liebermann-Burchard reaction (Pink-Blue-Green) and negative ferric and Shinoda test. Drugs used to treat tuberculosis are classified into first-line and second-line agents. The glycone can consist of a single sugar group (monosaccharide) or several sugar groups (oligosaccharide).

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