tandem autologous stem cell transplant multiple myeloma

Posted on October 8th, 2020


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Myeloma researcher Luciano Costa, MD along with United States and international colleagues wanted to compare the two approaches, knowing that the auto/allo combination may be able to provide additional graft vs. myeloma effect, but could also have higher incidence of lasting side effects. Biol Blood Marrow Transplant. Morgan GJ, Davies FE, Gregory WM, Cocks K, Bell SE, Szubert AJ, et al. Anticancer Res. 2000 Jun 15;95(12):4008-10. Blood. Morgan GJ, Gregory WM, Davies FE, et al. [Medline]. [Medline]. 158(17):1889-93. Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma. Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients. 2009 Apr 10. All rights reserved. Data are presented on 81 multiple myeloma (MM) patients with renal failure (creatinine > 176.8 micromol/l) at the time of autologous stem cell transplantation (auto-SCT), including 38 patients on dialysis. Rajkumar S, Fonseca R, Lacy M, et al. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. 1988;41(12):1209-13. Palumbo A, Bringhen S, Petrucci MT, Musto P, Rossini F, Nunzi M, Lauta VM, Bergonzi C, Barbui A, Caravita T, Capaldi A, Pregno P, Guglielmelli T, Grasso M, Callea V, Bertola A, Cavallo F, Falco P, Rus C, Massaia M, Mandelli F, Carella AM, Pogliani E, Liberati AM, Dammacco F, Ciccone G, Boccadoro M. Intermediate-dose melphalan improves survival of myeloma patients aged 50 to 70: results of a randomized controlled trial. [Guideline] Rizzo JD, Brouwers M, Hurley P, Seidenfeld J, Arcasoy MO, Spivak JL, et al.

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Believer that patients can help accelerate a cure by weighing in and participating in clinical trials. 2008 Apr 15.

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Now 20 years later, patients are better risk stratified and new transplant procedures have improved the survival and lowered side effects of allo transplant. Bone marrow biopsy demonstrating sheets of malignant plasma cells in multiple myeloma.

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[Full Text]. Erratum in: J Clin Oncol. The auto/allo approach clearly provided deeper responses, longer remissions and longer overall survival but also had a higher death rate. Kuehl WM, Bergsagel PL. 2008 Aug 15. 2004 Jun17;350(25):2628. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. A stem cell transplant, in combination with high-dose chemotherapy, is a treatment option that offers a chance for durable remission for people with multiple myeloma. Dimopoulos M, Terpos E, Comenzo RL, Tosi P, Beksac M, Sezer O, et al. 2008 Nov. 81(5):329-43. http://www.nccn.org/professionals/physician_gls/pdf/myeloma.pdf, https://www.esmo.org/oncology-news/adding-isatuximab-to-pomalidomide-and-low-dose-dexamethasone-improves-pfs-in-relapsed-and-refractory-multiple-myeloma, http://www.cancer.org/cancer/multiplemyeloma/detailedguide/multiple-myeloma-key-statistics, http://seer.cancer.gov/statfacts/html/mulmy.html, https://www.cancer.gov/news-events/cancer-currents-blog/2019/lenalidomide-slows-progression-smoldering-myeloma, http://www.medscape.com/viewarticle/807706, https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-carfilzomib-and-daratumumab-dexamethasone-multiple-myeloma, http://www.medscape.com/viewarticle/779048, https://www.fda.gov/drugs/drug-approvals-and-databases/fda-granted-accelerated-approval-belantamab-mafodotin-blmf-multiple-myeloma, https://www.nccn.org/professionals/physician_gls/pdf/vte.pdf, American Association for Cancer Education, American College of Clinical Pharmacology. Blood. 2012 May 10. van Nieuwenhuijzen N, Spaan I, Raymakers R, Peperzak V. From MGUS to Multiple Myeloma, a Paradigm for Clonal Evolution of Premalignant Cells.
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