Rona S. Weinberg PhD, in Transfusion Medicine and Hemostasis (Second Edition), 2013. This shows that HLA-confirmed monozygotic twins may still have anatomic differences. The recent finding that male DNA is frequently present in apheresis products from female donors suggests that donor fetal cells may be transferred during HCT.9,15  In addition, host (recipient) tolerance to fetal cells from prior pregnancies may be altered with myeloablative therapy, potentially explaining an association between sGVHD and recipient parity. Long-term results in 35 HLA-identical sibling and 3 HLA-identical parent-child renal allograft recipients. Median time to engraftment was 12 days in patients with ES vs. 11.5 days in those without ES. Copyright © 2004 by The American Society of Hematology, Copyright ©2020 by American Society of Hematology, https://doi.org/10.1182/blood-2004-02-0508. section 1734. Syngeneic sec-MLTC were established as described elsewhere (2).
Pulmonary: noncardiogenic pulmonary edema; with diffuse pulmonary infiltrates, hypoxia. By continuing you agree to the Use of Cookies. Patient characteristics: 15 (47%) were male; 28 (88%) had high-risk disease; 18 (56%) received total-body irradiation (TBI) as a component of myeloablative conditioning; 16 (50%) received donor peripheral blood stem cell infusion; and 14 (41%), 10 (31%) and 9 (28%) had low-, intermediate- and high-risk HCT-comorbidity index score respectively. Fever: temperature ≥100.9 F with no identifiable infectious etiology. Genetic testing in other sGVHD cases was more extensive: HLA/VNTR (n = 15), HLA/VNTR/RBC antigen/isoenzyme panel (n = 3), HLA/RBC antigen/isoenzyme panel (n = 1), and HLA only (n = 1). Control cultures were established with irradiated C57BL/6 normal spleen cells, to test for persisting background cytotoxicity. Ten days after inoculation of the cells, the developed tumors were measured in two dimensions and subjected to treatments. The 4T1 cell line for example has been shown to closely recapitulate human breast cancer immunogenicity, growth characteristics and metastatic properties (Pulaski and Ostrand-Rosenberg, 1998). Among 119 syngeneic hematopoietic cell transplant recipients, 21 developed biopsy-proven sGVHD, for a cumulative incidence of 18%. Five-year OS was 63% with ES versus 71% without (P = .80). Published by Elsevier Inc. All rights reserved. Fever, diffuse rash, diarrhea and transient renal dysfunction. Engraftment syndrome: double-edged sword of hematopoietic cell transplants. Hazard ratios (HRs) and associated 95% confidence intervals (CIs) were obtained using Cox proportional hazard regression models limited to 2 factors.

3 Donor/recipient pairs were assumed to be syngeneic when reported as such by the transplant centers, and date of birth and sex were identical.  |  HLA Class II typing was also by serology until the early 1990s, when it was replaced by molecular polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and SSP techniques. CNS: transient encephalopathy unexplainable by other causes. Liver transplantation: current status and novel approaches to liver replacement. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. Increased frequency of autoaggression syndrome associated with autologous stem cell transplantation in breast cancer patients. Steroids for diffuse alveolar hemorrhage. ☆Address requests for reprints to: Thomas D. Schiano, M.D., Divison of Liver Diseases, Box 1633, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, New York 10029. e-mail: Thomas.Schiano@msnyuhealth.org; fax: (212) 996-5149. Cumulative incidence estimates treated death, relapse, or second transplantation before day 100 as competing events for sGVHD.11  All survivors were censored 100 days after transplantation.

Immunosuppressive medications predispose recipients to infections and malignancies (both lymphoid and nonlymphoid). PBSC indicates peripheral blood stem cell; IL-2, interleukin-2; BUMELT, busulfan/melphalan/thiotepa; and NA, not applicable. Syngeneic murine brain tumor models offer us an opportunity to develop novel therapies for histologically similar human tumors.

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