shigella dysenteriae pathogenesis

Posted on October 8th, 2020

Anthony A. Nash, ... J. Ross Fitzgerald, in Mims' Pathogenesis of Infectious Disease (Sixth Edition), 2015. Son anaerobio facultativos, pero crecen mejor en condiciones aerobias. This second type of movement, also seen with intracellular Listeria monocytogenes, is accompanied by the appearance of ‘comet’-like rearrangements of actin in the cell. S. dysenteriae produce una exotoxina termolabil que afecta el intestino y el sistema nervioso central. Most users should sign in with their email address. In contrast there is now evidence that ShLTs are important in haemorrhagic colitis (HC) and haemolytic urea syndrome (HUS) caused by ShLT-producing strains of enterohaemorrhagic (EHEC) E. coli: EHEC has the capacity to progress disease beyond a watery diarrhoea stage to HC and HUS; the latter is characterised by renal failure, thrombocytopenia and microangiopathic haemolytic anaemia. In addition, Shigella infects macrophages, inducing IpaB-mediated apoptosis and IpaB-mediated release from those macrophages of IL-1β, another potent inflammatory cytokine. Shigella spp.

H. Chart, in Medical Microbiology (Eighteenth Edition), 2012. They are oxidase-negative, do not produce H2S (except for S. flexneri serotype 6 and S. boydii serotypes 13 and 14), and do not produce gas from glucose. Siendo Shigella dysenteriae la de mayor prevalencia. Interaction with PMN cells results in killing of organisms with concomitant release of tissue-damaging granules. Enteroinvasive E. coli (EIEC) isolates that cause a diarrheal illness identical to Shigella dysentery were identified in the 1970s (DuPont et al., 1971; Tulloch et al., 1973). For a long time it was thought that ShT was the principal cause of this disease. As members of the family Enterobacteriaceae, they are nearly genetically identical to the Escherichieae and closely related to the Salmonelleae [8].

As in dysentery, the role of ShLT in the causation of watery diarrhoea is controversial and indeed it may not be absolutely necessary.
From: Microbiology of Waterborne Diseases (Second Edition), 2014, Michel Drancourt, in Infectious Diseases (Fourth Edition), 2017.

Shigella spp. More striking is the observation that strains of EIEC are almost universally negative for lysine decarboxylase (LDC) activity whereas almost 90% of normal flora E. coli are positive. By contrast, EIEC resemble E. coli in their ability to ferment xylose and to produce gas from glucose, both traits for which Shigella are negative (Silva et al., 1980). Shigella are non-motile, Gram-negative rods. The latter is ruptured by the product of icsB gene, thereby releasing the organism into adjacent cells where rapid intracytoplasmic multiplication can again take place.

Nucleation and polymerisation of actin is mediated by virG (icsA). The Shiga bacillus is exceptional among enteric pathogens in possessing two potential pathogenetic modes of action, invasiveness and enterotoxin. are responsible for HUS.

Register, Oxford University Press is a department of the University of Oxford.

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