19, 207–213 (1963). Am. Delibrias, C. C., Kazatchkine, M. D. & Fischer, E. Evidence for the role of CR1 (CD35), in addition to CR2 (CD21), in facilitating infection of human T cells with opsonized HIV. They are integrated into the continuous stromal network within lymphoid organs.

Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Nature 470, 543–547 (2011). 191, 1082–1090 (2013). Temozolomide targets and arrests a doxorubicin-resistant follicular dendritic cell sarcoma patient-derived orthotopic xenograft (PDOX) mouse model. Stud. Smith-Franklin, B. Mellors, R. & Brzosko, W. Studies in molecular pathology. Follicular dendritic sarcoma masquerading as fibrosing mediastinitis.

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In mice lacking B cells, or with blocked TNF-a and lymphotoxin (LT) production, cells with FDC phenotype are missing.

Rev. Patients with FDCS usually present with cervical or axillary lymphadenopathy, but extranodal disease has been described. Tumors were positive for CD21, CD23, and CD35 in 83, 90, and 44% of cases, respectively. Mueller, S. N. et al. Case Rep Pathol. (GC). It is important to have a high index of suspicion, so follicular dendritic cell sarcoma is included in the differential diagnosis of a spindle cell neoplasm in the appropriate clinical and morphologic settings.

There are no pooled analyses of head and neck FDCS cases in the English language literature.

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Bull. Mandel, T., Phipps, R., Abbot, A. A filamentous collagen bundle that allows for the transport of low molecular weight (70 kDa, ∼5.5 nm) particles from the subcapsular sinus into the B cell follicle and the medulla. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.

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Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. Spontaneous Regression of Follicular Dendritic Cell Sarcoma.

PubMed  HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. Immunol. Follicular dendritic cells (FDCs) are cells of the immune system found in primary and secondary lymph follicles of the B cell areas of the lymphoid tissue. Impact of surgery, radiation and systemic therapy on the outcomes of patients with dendritic cell and histiocytic sarcomas. Separation of splenic red and white pulp occurs before birth in a LTαβ-independent manner. The natural history and response to different treatments have not been well established. Immunol.

The antigens are protected from damage by storage in non-degradative endosomal vesicles that periodically cycle to the cell surface. In eight patients the initial chemotherapy regimen was cyclophosphamide, doxorubicin, vincristine, and prednisone. 253, H1462–H1469 (1987). Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. Chen, L., Adams, J.

Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Alimzhanov, M. B. et al. Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Garin, A. et al.

Hepatic Follicular Dendritic Cell Sarcoma Favorably Controlled by Transcatheter Arterial Chemoembolization. Mediastinal follicular dendritic cell sarcoma: a rare, potentially under-recognized, and often misdiagnosed disease. Characteristics, management, and outcomes of patients with follicular dendritic cell sarcoma. Gonzalez, S. et al. J. Exp.

FDCs are among main producers of the chemokine CXCL13 which attracts and organises lymphoid cells.[11]. 168, 2408–2414 (2002). A., Siegert, S., Britschgi, M. R., Luther, S. A.

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