Does a diagnosis of smoldering myeloma guarantee that it will develop into actual multiple myeloma one day? Swelling or edema from the thalidomide, and particularly dexamethasone, will probably continue as long as she is on the drugs. The dysfunctional antibodies associated with these abnormal plasma cells form sheets of protein that can deposit into organs and nerves and interfere with their function. In some cases, the high eosinophil count has been attributed to medications the patient was taking. What else can be done for his pain and this disease? Among patients having an M protein less than 3 g/dl and IgG-type myeloma, with a normal MRI of the spine, median time to disease progression was 79 months, compared with 23 months among those with MRI involvement. If the multiple myeloma in fact ends her life at some time in the future, how does that usually occur? The best way to identify the extent of bone disease is with a skeletal survey - a series of X-rays of most of the bones in the body. Multiple myeloma causes of death - My partner was diagnosed in November 2005 with multiple myeloma stage III (renal failure and multiple lesions), suffered from a kidney injury, has undergone two stem cell transplants and is also completely remission after the second transplant in July 2006. Do you see high eosinophil counts in patients with multiple myeloma?

She has responded well to thalidomide but has come off the treatment recently due to some complications (swelling). Also, what is the usual outcome of a stem cell transplant? For example, if the median survival for stage I disease was 62 months, then half the people survived more than 62 months and half less than 62 months.) As it progresses, bone pain, anemia, kidney dysfunction, and infections may occur. Q2.

Try not to control deferred vysokorazvityh courses of corticosteroids.

Try not to send secondary treatment only, given the extreme run-time. She continues therapy with dexamethasone and thalidomide And follow-up visits. Generally, we should respond to a clear trend and not to just one or two readings. It is very unlikely that the myeloma would progress in the brief period he’s off the medications.

He takes oxycodone [Percolone].

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Q9. My dad has been diagnosed with multiple myeloma that has possibly metastasized, based on MRI and bone scan. If there is a high likelihood of aggressive disease coming back, you may want to consider aggressive “maintenance” treatment. Multiple myeloma (MM), also known as plasma cell myeloma and simple myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. The consultant said 2-4 weeks life expectancy...we are to expect hypercalcemia.

We do not yet know which patients are most likely to respond to Velcade. The response rates can be as good as 60 to 80 percent, with complete response rates ranging from 20 percent up to 40 percent. Prior to initiating treatment, your oncologist will probably have performed some tests on your blood to determine how aggressive or “poor risk” your myeloma was. Yes. Q8. He has been on thalidomide [Thalomid] and dexamethasone for four months, along with Zometa once monthly. We know it’s a worrying time for people with cancer, we have information to help. What usually causes death? In case cancer has metastasized to different parts of the body, the survival rate further decreases. He is going through other tests like PET scan and bone marrow test.

While multiple myeloma is not a curable disease, it is a treatable disease, and in the past eight to 10 years several new, effective drugs and drug combinations have become available to treat it.

She is now 77 and was 75 at the time of myeloma diagnosis.

My wife was diagnosed in November 2005 with stage III multiple myeloma (kidney distress and multiple lesions), suffered some kidney damage, has undergone two stem cell transplants and is in full remission since the second transplant in July 2006. I don't know if that is normal wear and tear or part of myeloma. The most common cause of death related to multiple myeloma is infection, with pneumonia being the most common fatal infection. What has been the result of the trials with Velcade?

Though thalidomide use has been associated with diarrhea, it is unusual that you are developing such symptoms now, after you have been on the drug without these problems for one year. However, having myeloma may have increased her susceptibility to one of these infections.

You should discuss these symptoms with your doctor as soon as possible.

His doctor now wants to start him on thalidomide and dexamethasone induction therapy, leading him into a stem cell transplant within a few months. A couple of months ago, a blood test determined that my father has smoldering myeloma. Or do people defy odds with no treatment for long?? Multiple Myeloma Remission Kappa and Lambda Light Chains. My parent came home from hospital 2 weeks ago ending all myeloma treatment. Is there a connection between myeloma and encephalitis? She has been in a wheelchair following compression fractures and the undiagnosed encephalitis (the symptoms being attributed to the myeloma). Transplant therapy is safe, with a smaller than 2 percent chance of the patient dying of complications from the therapy in good medical centers. Either way, this question should be discussed in detail with your doctor(s). For people with multiple myeloma who require … ADEM often occurs after exposure to immunizations, or infectious agents such as Epstein-Barr virus, cytomegalovirus, herpes simplex virus and mycoplasma. Treatment for multiple myeloma isn't always necessary for people who aren't experiencing any signs or symptoms. Sometimes doctors don't realize that patients don't have all of the information they need. Try not to control the radiation when you can make manifestations of the fundamental treatment. This suggests that Velcade may help to overcome the adverse effect of having deletion 13, but more data is needed to confirm this.

Doctors also use a cancer's stage when talking about survival statistics. He is not experiencing many symptoms at this point. Yet...they seem so healthy and full of energy and we are at the end of week 2.. they are on 10mg steroids daily so maybe this is helping but I'd really find it helpful to hear others experience of end stage. Is multiple myeloma, by the nature of the disease, considered to be metastatic? In a study of 10,750 patients with previously untreated symptomatic myeloma, the median survival of patients with stage I disease was 62 months (using the ISS). There is no absolute number separating good and bad disease.

The best people to ask would be someone in their medical team, who may have a better idea, but the end stage can be different for different people. My last two visits it has jumped up to 2.0. Edema can be reduced by making sure the legs are slightly elevated when your wife is sitting or in bed.

It is difficult to speculate on the lifespan of any one patient, but there is an International Staging System (ISS) for multiple myeloma which may give you a general idea of your father's prognosis. For which patients does Velcade work the best? Try not to change all the tough treatment because of problems with the visual response, if there is clinical benefit. While it is generally believed that all patients with asymptomatic (smoldering) myeloma will eventually develop symptomatic myeloma requiring therapy, the length of time that it takes for this progression to occur is quite variable. Eosinophils are a type of white blood cell. Thal-dex is one of the options for the start of therapy. One final word on this - if you feel that you don't know enough about the stage or extent of your myeloma, it's wise to ask your doctor for a clearer explanation.

Consequently, I don't believe the count increase is unexpected. Should we expect it to be sudden? She's continuing on dexamethasone and thalidomide and follow-up visits. With deletion 13? A retrospective study of 109 patients showed that risk factors for quicker progression to the symptomatic phase of myeloma include having an IgA-type M protein, an M protein greater than 3 g/dl, and bone marrow involvement on MRI of the spine. It’s really compromising how he’s felt recently. Q12. My husband had stem cell transplants for multiple myeloma last September (second treatment) and is on thalidomide (200 mg per day) and prednisone (50 mg every other day).

A cardiologist will be able to look for other explanations of these episodes if you have no evidence of amyloid deposition in the heart. And for those with stage III disease, it was 29 months. It helps determine how serious the cancer is and how best to treat it. What effect does Velcade have for patients with severe chromosome abnormalities? Kidney destruction or what? There seems to be a steady increase in the survival rates because of awareness among people and most importantly availability of the effective treatment options. The stage of a cancer describes how much cancer is in the body. Death will happen for all of us at one time or another. My gamma levels have stayed around 1.6.

The ISS relies on two blood tests, the albumin and the beta-2 microglobulin. I was diagnosed with smoldering myeloma in 2005. His numbers were at a plateau for over a year. If your disease is predicted to stay away for some time, then avoidance of toxic and aggressive therapy is very reasonable. The cause of multiple myeloma is unknown. If not, how do you determine if your myeloma has metastasized?

Is that usually the protocol, and what can I expect from the thal-dex regimen? (Deletion of chromosome 13 is a genetic abnormality associated with a more aggressive form of disease.) While pain medicines such as oxycodone are excellent, many individuals require further non-medicine measures. Velcade (bortezomib) kills myeloma cells by a different mechanism than any other drug available to treat myeloma.

His doctor suspects it’s due to the prednisone levels dropping. I think I have clostridium difficile colitis, but could it just be a side effect of the thalidomide? Sign up for our Cancer Care and Prevention Newsletter! You should bring these episodes of abnormal heart rhythms (bigeminy and trigeminy are two different patterns of abnormal heartbeats) to your hematologist's attention as well as to the attention a cardiologist. It can either be used by itself, or in combination with other drugs to treat myeloma. Q14. However, new clinical trials are being developed to reexamine this approach. My X-rays are fairly okay – no lesions, just some degeneration. Some days are worse than others. Should we expect it to be …

Overall, given your husband's young age, moving toward a transplant seems wise. The people who are diagnosed with multiple myeloma at an early stage will have a higher survival rate of up to 72%. Is this something that I need to discuss with my hematologist?

Q13. Feel free to read here for more information on the final weeks.

The consultant said 2-4 weeks life expectancy...we are to expect hypercalcemia. Learn. Previously, I believe they were 1.8 to 1.9.

There are also blood tests which your doctor will obtain to assess the amount of cancer cells in the body, but those tests will not tell you where the disease is - only an approximation of how much there is. Forum Name: Multiple Myeloma Question: Signs of death from multiple myeloma Lexy Dacosta - Thu Sep 29, 2005 8:51 am: Share |:( My mother is 73 years old and was diagnosed approximately 5 years ago with mulitple myeloma.

Rather than produce helpful antibodies, the cancer cells produce abnormal proteins that can cause complications. During the asymptomatic phase of disease, I recommend follow-up by an oncologist at least every two months. Amyloid deposition is just one of several reasons that you may be experiencing arrhythmia. Can you please provide some thoughts on his condition, including possible lifespan?

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